Recent studies have transformed our understanding of RNA from being viewed as an inert messenger or structural scaffold into a dynamic and multifunctional molecule with enzymatic activities that significantly influence genome architecture and function.

In our laboratory, we focus on unraveling the mechanisms that regulate RNA processing, stability, and function. We investigate how these RNA dynamics shape cellular responses to environmental changes and drive ribosome function, the essential molecular factory for protein synthesis. By studying selective RNA degradation, splicing, and ribosome biogenesis, we aim to understand how RNA synthesis and stability influence ribosome heterogeneity and the selective translation of proteins, processes that are critical for tumor progression and cellular adaptation to stress.